Question What is the likelihood of the overdiagnosis of breast cancer in women older than 70 years after screening? Conclusion Overdiagnosis — the identification of, in this case, breast cancer, that would not have caused symptoms in a person’s lifetime…

Denosumab use is not restricted to individuals with osteoporosis who have advanced kidney disease. However, concerns remain regarding the risk of severe hypocalcemia in such patients. In a cohort study of 2804 female patients (aged ≥65 years) with osteoporosis and…

Question Does the monoclonal antibody sarilumab facilitate the tapering of glucocorticoid therapy in patients with polymyalgia rheumatica? Conclusion Giving patients with PMR sarilumab twice monthly for 1 year allows an accelerated tapering regimen that greatly reduces the cumulative steroid dose…

Question Are patients with nonerosive gastroesophageal disease at an increased risk of esophageal cancer as compared with the average population? Conclusion We can reassure our patients (and ourselves) that nonerosive GERD does not increase the likelihood of esophageal cancer. Erosive…

Question How long do symptoms last after successful treatment of lower limb cellulitis? Conclusion Despite successful treatment of lower limb cellulitis, signs and symptoms of inflammation can still be present 10 days after treatment begins. These remnants do not indicate…

Question Is twice-daily low-dose aspirin noninferior to a low-molecular-weight heparin for thromboprophylaxis after an extremity, acetabular, or pelvic fracture? Conclusion Aspirin is noninferior to enoxaparin for thromboprophylaxis following inpatient treatment of a fracture. It is, of course, much cheaper, more…

Question How long do ankle arthroplasties last? Conclusion Using national registry data linked to the national healthcare database, 90% of ankle arthroplasties last 5 years. 2b Reference Jennison T, Ukoumunne O, Lamb S, Sharpe I, Goldberg AJ. How long do ankle…

Question In adults with prediabetes, can vitamin D supplementation decrease their likelihood of developing type 2 diabetes over several years? Conclusion In adults with prediabetes, can vitamin D supplementation decrease their likelihood of developing type 2 diabetes over several years?…

Question Is open repair or minimally invasive surgery better than nonoperative management for adults with acute Achilles tendon rupture? Conclusion There is no clear benefit to surgery over nonoperative management for adults with acute Achilles tendon rupture. Symptomatic improvement is…

Question Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee? Conclusion This is yet another study — this one of higher quality than the others…