Question Are patients with nonerosive gastroesophageal disease at an increased risk of esophageal cancer as compared with the average population? Conclusion We can reassure our patients (and ourselves) that nonerosive GERD does not increase the likelihood of esophageal cancer. Erosive…

Question How long do symptoms last after successful treatment of lower limb cellulitis? Conclusion Despite successful treatment of lower limb cellulitis, signs and symptoms of inflammation can still be present 10 days after treatment begins. These remnants do not indicate…

Question Is twice-daily low-dose aspirin noninferior to a low-molecular-weight heparin for thromboprophylaxis after an extremity, acetabular, or pelvic fracture? Conclusion Aspirin is noninferior to enoxaparin for thromboprophylaxis following inpatient treatment of a fracture. It is, of course, much cheaper, more…

Question How long do ankle arthroplasties last? Conclusion Using national registry data linked to the national healthcare database, 90% of ankle arthroplasties last 5 years. 2b Reference Jennison T, Ukoumunne O, Lamb S, Sharpe I, Goldberg AJ. How long do ankle…

Question In adults with prediabetes, can vitamin D supplementation decrease their likelihood of developing type 2 diabetes over several years? Conclusion In adults with prediabetes, can vitamin D supplementation decrease their likelihood of developing type 2 diabetes over several years?…

Question Is open repair or minimally invasive surgery better than nonoperative management for adults with acute Achilles tendon rupture? Conclusion There is no clear benefit to surgery over nonoperative management for adults with acute Achilles tendon rupture. Symptomatic improvement is…

Question Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee? Conclusion This is yet another study — this one of higher quality than the others…

Question Is the combination of physical therapy and an ultrasonography-guided corticosteroid injection safe and beneficial for the treatment of Achilles tendinopathy? Conclusion This study found that the addition of an ultrasonography-guided corticosteroid injection to standard physical therapy for the treatment…

Question How do ibuprofen, ketorolac, and diclofenac compare for the treatment of acute, nonradicular low back pain in adults? Conclusion This study found no differences among ibuprofen, ketorolac, and diclofenac in the primary outcome of overall clinical improvement at 5…

Question Is there an association between gastric cancer and the use of proton pump inhibitors? Conclusion This is the strongest evidence to date that there is a small but clinically significant increase in the risk of gastric cancer for patients…