Question Is leukocyte-rich plasma less effective than leukocyte-poor plasma when injected into the knees of adults with osteoarthritis? Conclusion In this study limited by the absence of a placebo wing, leukocyte-rich and leukocyte-poor PRP injections were comparably effective in relieving…

Question Is an intramuscular glucocorticoid injection noninferior to an intra-articular glucocorticoid injection in reducing knee pain in adults with knee osteoarthritis? Conclusion This study found that IA glucocorticoid injection may work better for reducing pain from knee OA at 1…

Question Are postoperative opioids more effective than nonopioids in reducing pain after minor or moderate surgical procedures? Conclusion In this well-done systematic review, opioids for managing postoperative pain following minor or moderate surgery were no more effective than nonopioids and…

Question Does intensive urate lowering improve outcomes in persons with erosive gout? Conclusion In adults with erosive gout, intensive urate lowering is difficult to achieve, takes a lot of medications, and does not improve outcomes. Reference Dalbeth N, Doyle AJ,…

Question Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee? Conclusion This is yet another study — this one of higher quality than the others…

Question What is the best dose of aspirin for secondary prevention in persons with established atherosclerotic cardiovascular disease? Conclusion There is no advantage to a 325-mg dose of aspirin for patients with established atherosclerotic cardiovascular disease (ASCVD), and people taking…

Question How do ibuprofen, ketorolac, and diclofenac compare for the treatment of acute, nonradicular low back pain in adults? Conclusion This study found no differences among ibuprofen, ketorolac, and diclofenac in the primary outcome of overall clinical improvement at 5…

Question Are platelet-rich plasma injections effective for alleviating pain and improving function in adults with symptomatic ankle osteoarthritis? Conclusion This study found no evidence that supports a benefit of PRP injections compared with saline placebo injections for improving function or…

Question What is the incidence and timing of recurrent herpes zoster in older adults? Conclusion The incidence of recurrent herpes zoster is comparable with the incidence of a first episode zoster infection, supporting the benefit of vaccination for individuals with…

Question Do muscle relaxants provide relief for nonspecific lower back pain? Conclusion Stick with nonsteroidal anti-inflammatories for the treatment of low back pain. Despite being used for almost 50 years to treat low back pain, the evidence supporting benzodiazepine or…