Question Is 7 days of antibiotic therapy noninferior to 14 days of therapy when treating urinary tract infection symptoms in afebrile men? Conclusion This study found that 7 days of antibiotic therapy with either ciprofloxacin or trimethoprim/sulfamethoxazole is noninferior to…

Question Is high-frequency spinal cord stimulation added to conventional medical management effective in alleviating pain in persons with painful diabetic neuropathy refractory to medical therapy? Conclusion Is high-frequency spinal cord stimulation added to conventional medical management effective in alleviating pain…

Question What is the optimal duration of oral antibiotic therapy after surgical treatment for prosthetic hip or knee joint infections? Conclusion Following surgical treatment for prosthetic joint infections, a 6-week course of oral antibiotic therapy is not as effective as…

Question Are multiple intra-articular corticosteroid injections more effective and safer than other joint injections in patients with degenerative joint disease? Conclusion In this systematic review, patients with degenerative joint disease who received multiple corticosteroid injections did not have more meaningful…

Question Are flat flexible shoes as effective as stable supportive shoes to decrease pain in patients with knee osteoarthritis? Conclusion Tell patients with knee pain to experiment to see if changing their shoe type produces pain relief. In this study,…

The Drug The U.S. Food and Drug Administration (FDA) has approved Saphnelo™ (anifrolumab-fnia) as a treatment for adults with systemic lupus erythematosus (SLE) who are receiving standard therapy. It is the third U.S. FDA approval of a lupus therapy since…

Question How accurate are rapid antigen tests for COVID-19 in both asymptomatic and symptomatic patients? Conclusion A rapid antigen test (Sofia FIA from Quidel) was highly specific, but sensitivity was 80% in symptomatic patients and only 40% in asymptomatic patients.…

Question For patients with sciatica, do epidural corticosteroid injections safely reduce pain and disability? Conclusion Epidural corticosteroid injections provide a small and probably clinically insignificant reduction in leg and back pain in the immediate term (< 2 weeks), and a…

Question Are ultrasound-guided intra-articular steroid injections more accurate than blind injections? Conclusion In this study from at a single center where steroid injections were given by a single experienced clinician, ultrasound (US)-guided intra-articular injections were more accurate than blind injection.…

Question Does convalescent plasma improve outcomes in patients hospitalized with severe pneumonia due to SARS-CoV-2? Conclusion In this study, convalescent plasma did not improve outcomes in patients hospitalized with severe COVID-19 pneumonia. Reference Simonovich VA, Burgos Pratx LD, Scibona P,…