Question Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee? Conclusion This is yet another study — this one of higher quality than the others…

Question Is the combination of physical therapy and an ultrasonography-guided corticosteroid injection safe and beneficial for the treatment of Achilles tendinopathy? Conclusion This study found that the addition of an ultrasonography-guided corticosteroid injection to standard physical therapy for the treatment…

Question How do ibuprofen, ketorolac, and diclofenac compare for the treatment of acute, nonradicular low back pain in adults? Conclusion This study found no differences among ibuprofen, ketorolac, and diclofenac in the primary outcome of overall clinical improvement at 5…

Question Is there an association between gastric cancer and the use of proton pump inhibitors? Conclusion This is the strongest evidence to date that there is a small but clinically significant increase in the risk of gastric cancer for patients…

Question Is leukocyte-rich plasma less effective than leukocyte-poor plasma when injected into the knees of adults with osteoarthritis? Conclusion In this study limited by the absence of a placebo wing, leukocyte-rich and leukocyte-poor PRP injections were comparably effective in relieving…

Question Is an intramuscular glucocorticoid injection noninferior to an intra-articular glucocorticoid injection in reducing knee pain in adults with knee osteoarthritis? Conclusion This study found that IA glucocorticoid injection may work better for reducing pain from knee OA at 1…

Question Are postoperative opioids more effective than nonopioids in reducing pain after minor or moderate surgical procedures? Conclusion In this well-done systematic review, opioids for managing postoperative pain following minor or moderate surgery were no more effective than nonopioids and…

Question Does intensive urate lowering improve outcomes in persons with erosive gout? Conclusion In adults with erosive gout, intensive urate lowering is difficult to achieve, takes a lot of medications, and does not improve outcomes. Reference Dalbeth N, Doyle AJ,…

Question Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee? Conclusion This is yet another study — this one of higher quality than the others…

Question What is the best dose of aspirin for secondary prevention in persons with established atherosclerotic cardiovascular disease? Conclusion There is no advantage to a 325-mg dose of aspirin for patients with established atherosclerotic cardiovascular disease (ASCVD), and people taking…