ADARRC

About ADARRC

This author has not yet filled in any details.
So far ADARRC has created 18 blog entries.

Multiple steroid injections into arthritic joints do not improve outcomes more than other injections

2021-09-20T15:54:44+04:00

Are multiple intra-articular corticosteroid injections more effective and safer than other joint injections in patients with degenerative joint disease? In this systematic review, patients with degenerative joint disease who received multiple corticosteroid injections did not have more meaningful pain relief than those who received other injections. Since 2 studies reported either cartilage loss or joint space narrowing among steroid-treated patients, more data are needed to determine just how safe they are. Ayub S, Kaur J, Hui M, et al. Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational [...]

Multiple steroid injections into arthritic joints do not improve outcomes more than other injections2021-09-20T15:54:44+04:00

Type of shoe doesn’t seem to matter for moderate to severe knee osteoarthritis due to medial joint space narrowing

2021-09-20T11:39:34+04:00

Are flat flexible shoes as effective as stable supportive shoes to decrease pain in patients with knee osteoarthritis? Tell patients with knee pain to experiment to see if changing their shoe type produces pain relief. In this study, supportive shoes produce a little more pain relief in patients with moderate to severe osteoarthritis than minimalist flat and flexible shoes, but the difference is not likely clinically relevant. Function, knee-related quality of life, and hip pain are not significantly better, on average, with one type of shoe over another, though patients in each group responded to their new shoes. Paterson [...]

Type of shoe doesn’t seem to matter for moderate to severe knee osteoarthritis due to medial joint space narrowing2021-09-20T11:39:34+04:00

FDA Approved Saphnelo™ (Anifrolumab-fnia) as a New Treatment for Lupus

2021-08-23T10:33:53+04:00

The U.S. Food and Drug Administration (FDA) has approved Saphnelo™ (anifrolumab-fnia) as a treatment for adults with systemic lupus erythematosus (SLE) who are receiving standard therapy. It is the third U.S. FDA approval of a lupus therapy since 2011, expanding treatment options for this medically underserved and life-threatening autoimmune disease.Saphnelo inhibits a key protein in the immune system called the IFNAR receptor that acts as a transmitter, amplifying signals from tiny messengers called type I interferons. This process activates many parts of the immune system and can trigger major inflammation. Saphnelo dampens the excessive type I interferon signature found in [...]

FDA Approved Saphnelo™ (Anifrolumab-fnia) as a New Treatment for Lupus2021-08-23T10:33:53+04:00

Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons)

2021-06-27T10:04:10+04:00

How accurate are rapid antigen tests for COVID-19 in both asymptomatic and symptomatic patients? A rapid antigen test (Sofia FIA from Quidel) was highly specific, but sensitivity was 80% in symptomatic patients and only 40% in asymptomatic patients. In asymptomatic patients, due to the low prevalence in this sample (2%), there was also a high false positive rate of 67%. Pray IW, Ford L, Cole D, et al, for the CDC COVID-19 Surge Laboratory Group. Performance of an antigen-based test for asymptomatic and symptomatic SARS-CoV-2 testing at two university campuses - Wisconsin, September-October 2020. MMWR Morb Mortal Wkly Rep 2021;69(5152):1642–1647. [...]

Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons)2021-06-27T10:04:10+04:00

Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica

2021-06-27T10:01:49+04:00

For patients with sciatica, do epidural corticosteroid injections safely reduce pain and disability? Epidural corticosteroid injections provide a small and probably clinically insignificant reduction in leg and back pain in the immediate term (

Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica2021-06-27T10:01:49+04:00

Ultrasound-guided steroid injections are more accurate than blind injections for frozen shoulder, but outcomes are similar

2021-06-27T09:58:59+04:00

Are ultrasound-guided intra-articular steroid injections more accurate than blind injections? In this study from at a single center where steroid injections were given by a single experienced clinician, ultrasound (US)-guided intra-articular injections were more accurate than blind injection. But the outcomes, even among those that "missed," were similar. Cho CH, Min BW, Bae KC, Lee KJ, Kim DH. A prospective double-blind randomized trial on ultrasound-guided versus blind intra-articular corticosteroid injections for primary frozen shoulder. Bone Joint J 2021;103-B(2):353-359.

Ultrasound-guided steroid injections are more accurate than blind injections for frozen shoulder, but outcomes are similar2021-06-27T09:58:59+04:00

Convalescent plasma does not improve outcomes in patients hospitalized with severe COVID-19 pneumonia (PlasmAr)

2021-06-27T09:53:32+04:00

Does convalescent plasma improve outcomes in patients hospitalized with severe pneumonia due to SARS-CoV-2? In this study, convalescent plasma did not improve outcomes in patients hospitalized with severe COVID-19 pneumonia. Simonovich VA, Burgos Pratx LD, Scibona P, et al, for the PlasmAr Study Group. A randomized trial of convalescent plasma in Covid-19 severe pneumonia. N Engl J Med 2021;384(7):619-629.

Convalescent plasma does not improve outcomes in patients hospitalized with severe COVID-19 pneumonia (PlasmAr)2021-06-27T09:53:32+04:00

Tofacitinib Does Not Increase Risk of Venous Thromboembolism in Patients With RA

2021-06-27T09:53:03+04:00

Does Tofacitinib Increase the Risk of Venous Thromboembolism in Patients with RA? Recently, a link between venous thromboembolism (VTE) and Janus Kinase (JAK) inhibitors has emerged, causing the FDA to recommend a black box label for tofacitinib in 2019. New research, however, suggests that tofacitinib had similarly infrequent cases of VTE (<1 per 100) when compared with tumor necrosis factor inhibitors (TNFIs). Desai RJ, Pawar A, Khosrow-Khavar F, Weinblatt ME, Kim SC. Risk of venous thromboembolism associated with tofacitinib in patients with rheumatoid arthritis: a population-based cohort study [published online ahead of print, 2021 Mar 22]. Rheumatology (Oxford). 2021;keab294. [...]

Tofacitinib Does Not Increase Risk of Venous Thromboembolism in Patients With RA2021-06-27T09:53:03+04:00

Tocilizumab and sarilumab are effective for critically ill patients with COVID-19 who require organ support

2021-06-27T09:52:25+04:00

Are monoclonal antibodies against the interleukin-6 receptor effective in patients who are critically ill with COVID-19? In patients who are critically ill with COVID-19 and require respiratory or cardiovascular organ support, the monocloncal antibodies tocilizumab and sarilumab reduce mortality (number needed to treat [NNT] = 12) and decrease the need for organ support during the 3 weeks following the initiation of therapy. As we have seen with other studies of COVID-19 therapies, benefit is often restricted to specific groups, and this result should not be generalized to less ill patients for whom the benefit has not been demonstrated. The [...]

Tocilizumab and sarilumab are effective for critically ill patients with COVID-19 who require organ support2021-06-27T09:52:25+04:00

Single-dose opioid analgesics offer no benefit over non-narcotic analgesia for musculoskeletal pain

2021-06-27T09:51:27+04:00

For acute muscle pain, what oral analgesic provides the best immediate relief? A single dose of opioid analgesics provides similar acute pain relief to a single dose of a combination of acetaminophen and ibuprofen in patients with acute musculoskeletal pain in the emergency department. Opioids increase the likelihood of nausea or vomiting. There was no added benefit of 800 mg of ibuprofen as compared with 400 mg. Unfortunately, the study did not investigate the further effect, possibly because of the placebo effect, of an injectable analgesic. These results are similar to those of previous studies of opioids and different doses [...]

Single-dose opioid analgesics offer no benefit over non-narcotic analgesia for musculoskeletal pain2021-06-27T09:51:27+04:00
Go to Top