ADARRC

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So far ADARRC has created 31 blog entries.

No difference in resolution of urinary tract infection symptoms with 7 vs 14 days of antibiotic therapy among afebrile men

2021-10-24T15:17:14+04:00

Is 7 days of antibiotic therapy noninferior to 14 days of therapy when treating urinary tract infection symptoms in afebrile men? This study found that 7 days of antibiotic therapy with either ciprofloxacin or trimethoprim/sulfamethoxazole is noninferior to 14 days of treatment for UTI symptoms among afebrile men. Drekonja DM, Trautner B, Amundson C, Kuskowski M, Johnson JR. Effect of 7 vs 14 days of antibiotic therapy on resolution of symptoms among afebrile men with urinary tract infection. A randomized clinical trial. JAMA 2021326(4):324-331.

No difference in resolution of urinary tract infection symptoms with 7 vs 14 days of antibiotic therapy among afebrile men2021-10-24T15:17:14+04:00

High-frequency spinal cord stimulation improves pain in patients with refractory painful diabetic neuropathy

2021-10-24T15:15:09+04:00

Is high-frequency spinal cord stimulation added to conventional medical management effective in alleviating pain in persons with painful diabetic neuropathy refractory to medical therapy? In this study with multiple biases in favor of intervention, patients with painful diabetic neuropathy treated with conventional medical management plus high-frequency spinal cord stimulation (CMM+SCS) experienced dramatic improvement compared with those who continued to use their previous ineffective therapy. Given the methodologic issues with this study, more rigorous trials are needed. Petersen EA, Stauss TG, Scowcroft JA, et al. Effect of high-frequency (10-kHz) spinal cord stimulation in patients with painful diabetic neuropathy: a randomized clinical [...]

High-frequency spinal cord stimulation improves pain in patients with refractory painful diabetic neuropathy2021-10-24T15:15:09+04:00

More unfavorable outcomes with 6 weeks versus 12 weeks of oral antibiotic therapy for prosthetic joint infections

2021-09-29T08:51:06+04:00

What is the optimal duration of oral antibiotic therapy after surgical treatment for prosthetic hip or knee joint infections? Following surgical treatment for prosthetic joint infections, a 6-week course of oral antibiotic therapy is not as effective as a 12-week course and leads to a higher number of persistent or recurrent infections at 2 years. Bernard L, Arvieux C, Brunschweiler B, et al. Antibiotic therapy for 6 or 12 weeks for prosthetic joint infection. N Engl J Med 2021;384(21):1991-2001.

More unfavorable outcomes with 6 weeks versus 12 weeks of oral antibiotic therapy for prosthetic joint infections2021-09-29T08:51:06+04:00

Multiple steroid injections into arthritic joints do not improve outcomes more than other injections

2021-09-20T15:54:44+04:00

Are multiple intra-articular corticosteroid injections more effective and safer than other joint injections in patients with degenerative joint disease? In this systematic review, patients with degenerative joint disease who received multiple corticosteroid injections did not have more meaningful pain relief than those who received other injections. Since 2 studies reported either cartilage loss or joint space narrowing among steroid-treated patients, more data are needed to determine just how safe they are. Ayub S, Kaur J, Hui M, et al. Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational [...]

Multiple steroid injections into arthritic joints do not improve outcomes more than other injections2021-09-20T15:54:44+04:00

Type of shoe doesn’t seem to matter for moderate to severe knee osteoarthritis due to medial joint space narrowing

2021-09-20T11:39:34+04:00

Are flat flexible shoes as effective as stable supportive shoes to decrease pain in patients with knee osteoarthritis? Tell patients with knee pain to experiment to see if changing their shoe type produces pain relief. In this study, supportive shoes produce a little more pain relief in patients with moderate to severe osteoarthritis than minimalist flat and flexible shoes, but the difference is not likely clinically relevant. Function, knee-related quality of life, and hip pain are not significantly better, on average, with one type of shoe over another, though patients in each group responded to their new shoes. Paterson [...]

Type of shoe doesn’t seem to matter for moderate to severe knee osteoarthritis due to medial joint space narrowing2021-09-20T11:39:34+04:00

FDA Approved Saphnelo™ (Anifrolumab-fnia) as a New Treatment for Lupus

2021-08-23T10:33:53+04:00

The U.S. Food and Drug Administration (FDA) has approved Saphnelo™ (anifrolumab-fnia) as a treatment for adults with systemic lupus erythematosus (SLE) who are receiving standard therapy. It is the third U.S. FDA approval of a lupus therapy since 2011, expanding treatment options for this medically underserved and life-threatening autoimmune disease.Saphnelo inhibits a key protein in the immune system called the IFNAR receptor that acts as a transmitter, amplifying signals from tiny messengers called type I interferons. This process activates many parts of the immune system and can trigger major inflammation. Saphnelo dampens the excessive type I interferon signature found in [...]

FDA Approved Saphnelo™ (Anifrolumab-fnia) as a New Treatment for Lupus2021-08-23T10:33:53+04:00

Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons)

2021-06-27T10:04:10+04:00

How accurate are rapid antigen tests for COVID-19 in both asymptomatic and symptomatic patients? A rapid antigen test (Sofia FIA from Quidel) was highly specific, but sensitivity was 80% in symptomatic patients and only 40% in asymptomatic patients. In asymptomatic patients, due to the low prevalence in this sample (2%), there was also a high false positive rate of 67%. Pray IW, Ford L, Cole D, et al, for the CDC COVID-19 Surge Laboratory Group. Performance of an antigen-based test for asymptomatic and symptomatic SARS-CoV-2 testing at two university campuses - Wisconsin, September-October 2020. MMWR Morb Mortal Wkly Rep 2021;69(5152):1642–1647. [...]

Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons)2021-06-27T10:04:10+04:00

Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica

2021-06-27T10:01:49+04:00

For patients with sciatica, do epidural corticosteroid injections safely reduce pain and disability? Epidural corticosteroid injections provide a small and probably clinically insignificant reduction in leg and back pain in the immediate term (

Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica2021-06-27T10:01:49+04:00

Ultrasound-guided steroid injections are more accurate than blind injections for frozen shoulder, but outcomes are similar

2021-06-27T09:58:59+04:00

Are ultrasound-guided intra-articular steroid injections more accurate than blind injections? In this study from at a single center where steroid injections were given by a single experienced clinician, ultrasound (US)-guided intra-articular injections were more accurate than blind injection. But the outcomes, even among those that "missed," were similar. Cho CH, Min BW, Bae KC, Lee KJ, Kim DH. A prospective double-blind randomized trial on ultrasound-guided versus blind intra-articular corticosteroid injections for primary frozen shoulder. Bone Joint J 2021;103-B(2):353-359.

Ultrasound-guided steroid injections are more accurate than blind injections for frozen shoulder, but outcomes are similar2021-06-27T09:58:59+04:00

Convalescent plasma does not improve outcomes in patients hospitalized with severe COVID-19 pneumonia (PlasmAr)

2021-06-27T09:53:32+04:00

Does convalescent plasma improve outcomes in patients hospitalized with severe pneumonia due to SARS-CoV-2? In this study, convalescent plasma did not improve outcomes in patients hospitalized with severe COVID-19 pneumonia. Simonovich VA, Burgos Pratx LD, Scibona P, et al, for the PlasmAr Study Group. A randomized trial of convalescent plasma in Covid-19 severe pneumonia. N Engl J Med 2021;384(7):619-629.

Convalescent plasma does not improve outcomes in patients hospitalized with severe COVID-19 pneumonia (PlasmAr)2021-06-27T09:53:32+04:00
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