Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee?
Question
Are platelet-rich plasma injections, either single or multiple, more effective than saline injections in adults with early symptomatic degenerative joint disease of the knee?
Conclusion
This is yet another study — this one of higher quality than the others — that finds PRP injections, singly or serially, to be no better than saline injections in improving outcomes in adults with mild radiographically confirmed degenerative joint disease of the knee.
Reference
Lewis E, Merghani K, Robertson I, et al. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial. Bone Joint J 2022;104-B(6):663-671.