No advantage to 325 mg over 81 mg aspirin for persons with established cardiovascular disease (ADAPTABLE)

AdARRC™ June 20, 2022 Monday Weekly Update
No advantage to 325 mg over 81 mg aspirin for persons with established cardiovascular disease (ADAPTABLE)

Question

What is the best dose of aspirin for secondary prevention in persons with established atherosclerotic cardiovascular disease?

Conclusion

There is no advantage to a 325-mg dose of aspirin for patients with established atherosclerotic cardiovascular disease (ASCVD), and people taking the higher dose often switched to the lower dose (although the reason is unclear). Just stick with 81 mg.

Reference

Jones WS, Mulder H, Wruck LM, et al. Comparative effectiveness of aspirin dosing in cardiovascular disease. N Engl J Med 2021;384(21):1981-1990.

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