Intravenous immune globulin plus corticosteroids is the best initial therapy for multisystem inflammatory syndrome in children AdARRC™ November 1, 2021 Monday Weekly Update Question What is the best treatment for multisystem inflammatory syndrome in children? Conclusion For children with MIS-C caused by SARS-CoV-2, the preferred initial treatment is IVIG plus corticosteroids. Reference Son MB, Murray N, Friedman K, et al, for the Overcoming COVID-19 Investigators. Multisystem inflammatory syndrome in children — initial therapy and outcomes. N Engl J Med 2021;385(1):23-34. Share This Post!