Question
Are interleukin-6 antagonists effective in decreasing mortality among persons hospitalized with COVID-19?
Conclusion
Based on this systematic review, it is unclear if IL-6 antagonists decrease mortality among persons hospitalized with COVID-19. Co-intervention with corticosteroids has muddied the waters, and the data so far are dominated by a single agent (tocilizumab). The other agents do not appear to be effective.
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