No benefit to remdesivir, HCQ, lopinavir, or interferon in large WHO trial of adults hospitalized with COVID-19 (Solidarity)

Are older antiviral drugs beneficial for adults hospitalized with COVID-19?

This large open-label randomized trial found no benefit to remdesivir, interferon, lopinavir, or hydroxychloroquine for adults hospitalized with COVID-19. The only possible benefit was seen with remdesivir in patients who required low-flow or no oxygen, but the absolute benefit, if any, was small.