Question
Are monoclonal antibodies against the interleukin-6 receptor effective in patients who are critically ill with COVID-19?
Conclusion
In patients who are critically ill with COVID-19 and require respiratory or cardiovascular organ support, the monocloncal antibodies tocilizumab and sarilumab reduce mortality (number needed to treat [NNT] = 12) and decrease the need for organ support during the 3 weeks following the initiation of therapy. As we have seen with other studies of COVID-19 therapies, benefit is often restricted to specific groups, and this result should not be generalized to less ill patients for whom the benefit has not been demonstrated.
Recent Posts
- Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults
- Another study fails to find PRP injections effective for adults with degenerative joint disease of the knee
- Short-term benefit from ultrasonography-guided steroid injection for Achilles tendinopathy
- How do ibuprofen, ketorolac, and diclofenac compare for the treatment of acute, nonradicular low back pain in adults?
- Is there an association between gastric cancer and the use of proton pump inhibitors?
Leave A Comment